Direct cell adhesion to the angiopoietins mediated by integrins.
AuthorsCarlson TR, Feng Y, Maisonpierre PC, Mrksich M, Morla AO
JournalJ Biol Chem
PubMed ID11346644
Genetic ablation of angiopoietin-1 (Ang-1) or of its cognate receptor, Tie2, disrupts angiogenesis in mouse embryos. The endothelial cells in growing blood vessels of Ang-1 knockout mice have a rounded appearance and are poorly associated with one another and their underlying basement membranes (Dumont, D. J., Gradwohl, G., Fong, G. ... More