Modulation of monocyte function by activated protein C, a natural anticoagulant.
AuthorsStephenson DA, Toltl LJ, Beaudin S, Liaw PC,
JournalJ Immunol
PubMed ID16887970
'Activated protein C is the first effective biological therapy for the treatment of severe sepsis. Although activated protein C is well established as a physiological anticoagulant, emerging data suggest that it also exerts anti-inflammatory and antiapoptotic effects. In this study, we investigated the ability of activated protein C to modulate ... More
In vitro degradation of bovine myofibrils is caused by µ-calpain, not caspase-3.
AuthorsMohrhauser DA, Underwood KR, Weaver AD,
JournalJ Anim Sci
PubMed ID20971887
'Tenderness is a key palatability trait influencing perception of consumers of meat quality and is influenced by a multitude of factors, including postmortem proteolysis. A fundamental understanding of this biological mechanism regulating tenderness is necessary to decrease variability and increase consumer satisfaction. However, reports regarding the enzyme systems involved in ... More
Photodynamic therapy and cell death pathways.
AuthorsKessel D, Oleinick NL,
JournalMethods Mol Biol
PubMed ID20552338
Photodynamic therapy (PDT) is the term used to describe the irradiation of photosensitized cells or tissue with phototoxic consequences. This process can result in the rapid initiation of not only apoptosis, an irreversible death pathway, but also autophagy. The procedures described here are designed to characterize the correlation between the ... More