Extension of Saccharomyces paradoxus chronological lifespan by retrotransposons in certain media conditions is associated with changes in reactive oxygen species.
AuthorsVanHoute D, Maxwell PH,
Journal
PubMed ID25106655
'Retrotransposons are mobile DNA elements present throughout eukaryotic genomes that can cause mutations and genome rearrangements when they replicate through reverse transcription. Increased expression and/or mobility of retrotransposons has been correlated with aging in yeast, Caenorhabditis elegans, Drosophila melanogaster, and mammals. The many copies of retrotransposons in humans and various ... More
Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy.
AuthorsZavodszky E, Seaman MN, Moreau K, Jimenez-Sanchez M, Breusegem SY, Harbour ME, Rubinsztein DC,
Journal
PubMed ID24819384
'Endosomal protein sorting controls the localization of many physiologically important proteins and is linked to several neurodegenerative diseases. VPS35 is a component of the retromer complex, which mediates endosome-to-Golgi retrieval of membrane proteins such as the cation-independent mannose 6-phosphate receptor. Furthermore, retromer is also required for the endosomal recruitment of ... More
Modulation of medium pH by caulobacter crescentus facilitates recovery from uranium-induced growth arrest.
AuthorsPark DM, Jiao Y,
Journal
PubMed ID25002429
The oxidized form of uranium [U(VI)] predominates in oxic environments and poses a major threat to ecosystems. Due to its ability to mineralize U(VI), the oligotroph Caulobacter crescentus is an attractive candidate for U(VI) bioremediation. However, the physiological basis for U(VI) tolerance is unclear. Here we demonstrated that U(VI) caused ... More
Role of betulinic acid derivative SH-479 in triple negative breast cancer and bone microenvironment.
Authors
JournalOncol Lett
PubMed ID34188707
Sacrificial-layer free transfer of mammalian cells using near infrared femtosecond laser pulses.
'Laser-induced cell transfer has been developed in recent years for the flexible and gentle printing of cells. Because of the high transfer rates and the superior cell survival rates, this technique has great potential for tissue engineering applications. However, the fact that material from an inorganic sacrificial layer, which is ... More
Inhibition of Mitochondrial ROS by MitoQ Alleviates White Matter Injury and Improves Outcomes after Intracerebral Haemorrhage in Mice.
AuthorsChen W, Guo C, Jia Z, Wang J, Xia M, Li C, Li M, Yin Y, Tang X, Chen T, Hu R, Chen Y, Liu X, Feng H
JournalOxid Med Cell Longev
PubMed ID31998445
'White matter injury (WMI) is an important cause of high disability after intracerebral haemorrhage (ICH). It is widely accepted that reactive oxygen species (ROS) contributes to WMI, but there is still no evidence-based treatment. Here, mitoquinone (MitoQ), a newly developed selective mitochondrial ROS scavenger, was used to test its neuroprotective ... More
Graphene Nanosheets to Improve Physico-Mechanical Properties of Bioactive Calcium Silicate Cements.
AuthorsDubey N, Rajan SS, Bello YD, Min KS, Rosa V,
JournalMaterials (Basel)
PubMed ID28772959
'Bioactive calcium silicate cements are widely used to induce mineralization, to cement prosthetic parts, in the management of tooth perforations, and other areas. Nonetheless, they can present clinical disadvantages, such as long setting time and modest physico-mechanical properties. The objective of this work was to evaluate the potential of graphene ... More
Quantitative determination of histone methylation via fluorescence resonance energy transfer (FRET) technology in immortalized bovine mammary alveolar epithelial cells supplemented with methionine.
Authors
JournalPLoS One
PubMed ID33347518
Tumor heterogeneity in autophagy-dependent ferroptosis.
Authors
JournalAutophagy
PubMed ID33404288
Synthetic Lethal Targeting of Mitotic Checkpoints in HPV-Negative Head and Neck Cancer.
Authors
JournalCancers (Basel)
PubMed ID32012873
Impact of Losing hRpn13 Pru or UCHL5 on Proteasome Clearance of Ubiquitinated Proteins and RA190 Cytotoxicity.
Authors
JournalMol Cell Biol
PubMed ID32631902
Extending Single Cell Bioprinting from Femtosecond to Picosecond Laser Pulse Durations.
Authors
JournalMicromachines (Basel)
PubMed ID34683222
Adipose-Derived Biogenic Nanoparticles for Suppression of Inflammation.
Authors
JournalSmall
PubMed ID32067382
Long noncoding RNA PCAT6 inhibits colon cancer cell apoptosis by regulating anti-apoptotic protein ARC expression via EZH2.
AuthorsHuang W, Su G, Huang X, Zou A, Wu J, Yang Y, Zhu Y, Liang S, Li D, Ma F, Guo L
JournalCell Cycle
PubMed ID30569799
Prostate cancer-associated ncRNA transcript 6 (PCAT6) is a long intergenic noncoding RNA that is involved in the progression of prostate and lung cancer, acting as a potential diagnostic and prognostic biomarker in nonsmall cell lung cancer. However, little is known about PCAT6 expression and its clinical significance in colon cancer. ... More
Anti-inflammatory and immune-modulating effects of rice callus suspension culture (RCSC) and bioactive fractions in an in vitro inflammatory bowel disease model.
AuthorsDriscoll K, Deshpande A, Chapp A, Li K, Datta R, Ramakrishna W
JournalPhytomedicine
PubMed ID30831485
Rice callus suspension culture (RCSC) has been shown to exhibit potent antiproliferative activity in multiple cancer cell lines. RCSC and its bioactive compounds can fill the need for drugs with no side effects. ... More