'The SPCs (subtilisin-like pro-protein convertases) are a family of enzymes responsible for the proteolytic processing of numerous precursor proteins of the constitutive and regulated secretory pathways. SPCs are themselves synthesized as inactive zymogens. Activation of SPCs occurs via the intramolecular autocatalytic removal of the prodomain. SPC prodomains have been proposed ... More
The human cytomegalovirus immediate early gene promoter is a strong promoter in cultured Drosophila melanogaster cells.
Authors Sinclair J H;
JournalNucleic Acids Res
PubMed ID3031595
None
A heterotrimeric death domain complex in Toll signaling.
Authors Sun Huaiyu; Bristow Benjamin N; Qu Guowei; Wasserman Steven A;
JournalProc Natl Acad Sci U S A
PubMed ID12351681
Signaling from the transmembrane receptor Toll to Rel-related transcription factors regulates dorsoventral patterning of the Drosophila embryo, as well as larval and adult immunity. To identify additional pathway components, we have used double-stranded RNA interference to investigate Drosophila counterparts of genes that regulate the mammalian Rel family member NF-kappaB. Experiments ... More
Drosophila Ack targets its substrate, the sorting nexin DSH3PX1, to a protein complex involved in axonal guidance.
Authors Worby Carolyn A; Simonson-Leff Nancy; Clemens James C; Huddler Donald Jr; Muda Marco; Dixon Jack E;
JournalJ Biol Chem
PubMed ID11773052
Dock, the Drosophila orthologue of Nck, is an adaptor protein that is known to function in axonal guidance paradigms in the fly including proper development of neuronal connections in photoreceptor cells and axonal tracking in Bolwig's organ. To develop a better understanding of axonal guidance at the molecular level, we ... More