Molecular emergence of acute myeloid leukemia during treatment for acute lymphoblastic leukemia.
Authors Blanco J G; Dervieux T; Edick M J; Mehta P K; Rubnitz J E; Shurtleff S; Raimondi S C; Behm F G; Pui C H; Relling M V;
JournalProc Natl Acad Sci U S A
PubMed ID11526240
Therapy-related acute myeloid leukemias (t-AML) with translocations of the MLL gene are associated with the use of topoisomerase II inhibitors. We established the emergence of the malignant clone in a child who developed t-AML with a t(11;19) (q23;p13.3) during treatment for acute lymphoblastic leukemia (ALL). The MLL-ENL and the reciprocal ... More