PKC-induced intracellular trafficking of Ca(V)2 precedes its rapid recruitment to the plasma membrane.
AuthorsZhang Y, Helm JS, Senatore A, Spafford JD, Kaczmarek LK, Jonas EA,
JournalJ Neurosci
PubMed ID18322103
'Activation of protein kinase C (PKC) potentiates secretion in Aplysia peptidergic neurons, in part by inducing new sites for peptide release at growth cone terminals. The mechanisms by which ion channels are trafficked to such sites are, however, not well understood. We now show that PKC activation rapidly recruits new ... More