Characterization of the SECIS binding protein 2 complex required for the co-translational insertion of selenocysteine in mammals.
AuthorsKinzy SA, Caban K, Copeland PR,
JournalNucleic Acids Res
PubMed ID16155186
'Selenocysteine is incorporated into at least 25 human proteins by a complex mechanism that is a unique modification of canonical translation elongation. Selenocysteine incorporation requires the concerted action of a kink-turn structural RNA (SECIS) element in the 3'' untranslated region of each selenoprotein mRNA, a selenocysteine-specific translation elongation factor (eEFSec) ... More