Surface antigen expression and immunoglobulin gene rearrangement during mouse pre-B cell development.
AuthorsCoffman RL
JournalImmunol Rev
PubMed ID6984001
'The first part of this article discusses the isolation and characterization of several monoclonal antibodies to the B lineage-specific surface molecule, B220. B220 was shown to be expressed on precursors of B cells by the demonstration that removal of B220+ cells from B cell-depleted bone marrow removes the ability of ... More
Ligation of CD45 on B cells can facilitate production of secondary Ig isotypes.
AuthorsGeorge A, Rath S, Shroff KE, Wang M, Durdik JM
JournalJ Immunol
PubMed ID8301113
'The possibility that isotype switching in B cells may be affected by engagement of the CD45 molecule on B cells has been investigated in microcultures containing limiting numbers of B cells and nonlimiting numbers of both alloreactive Th cells and purified dendritic cells (DC). Addition of Abs to the B ... More
Administration of anti-CD45 mAb specific for a B cell-restricted epitope abrogates the B cell response to a T-dependent antigen in vivo.
AuthorsDomiati-Saad R, Ogle EW, Justement LB
JournalJ Immunol
PubMed ID7504011
CD45 is a receptor-like protein tyrosine phosphatase expressed exclusively by cells of the hemopoietic lineage. Studies in vitro involving treatment of B cells with anti-CD45 mAb have demonstrated that ligand binding to CD45 alters the cell's response to various activation/differentiation stimuli. In general anti-CD45 treatment has been shown to exert ... More