Interleukin-12 is required for interferon-gamma production and lethality in lipopolysaccharide-induced shock in mice.
AuthorsWysocka M, Kubin M, Vieira LQ, Ozmen L, Garotta G, Scott P, Trinchieri G
JournalEur J Immunol
PubMed ID7705395
Several cytokines, in particular tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma), have been shown to be responsible for pathological reactions which may lead to shock and death observed in infection with Gram-negative bacteria and in response to endotoxins (lipopolysaccharides, LPS). Priming of mice with the avirulent Bacille Calmette Guérin (BCG) ... More