Kupffer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes.
AuthorsSunman JA, Hawke RL, LeCluyse EL, Kashuba AD,
JournalDrug Metab Dispos
PubMed ID14977871
Interleukin (IL)-2 administration has been shown to decrease CYP3A enzyme activity in vivo. To determine whether IL-2 suppression of human hepatocyte CYP3A activity is direct or whether it is facilitated by the presence of Kupffer cells, primary human hepatocytes were cultured alone or cocultured with primary human Kupffer cells at ... More