A novel mechanism of neurokinin-1 receptor resensitization.
AuthorsBennett VJ, Perrine SA, Simmons MA
JournalJ Pharmacol Exp Ther
PubMed ID12438539
Prolonged or repeated activation of many G protein-coupled receptors induces rapid desensitization followed by a period during which receptors are resensitized. In this study, concanavalin A (Con A) and monensin were used to investigate the mechanisms of desensitization and resensitization of the neurokinin-1 receptor. Con A inhibits internalization, whereas monensin ... More