Identification of nicotinic acetylcholine receptor recycling and its role in maintaining receptor density at the neuromuscular junction in vivo.
AuthorsBruneau E, Sutter D, Hume RI, Akaaboune M
JournalJ Neurosci
PubMed ID16251443
'In the CNS, receptor recycling is critical for synaptic plasticity; however, the recycling of receptors has never been observed at peripheral synapses. Using a novel imaging technique, we show here that nicotinic acetylcholine receptors (AChRs) recycle into the postsynaptic membrane of the neuromuscular junction. By sequentially labeling AChRs with biotin-bungarotoxin ... More
The Nef protein of human immunodeficiency virus is a broad-spectrum modulator of chemokine receptor cell surface levels that acts independently of classical motifs for receptor endocytosis and Galphai signaling.
AuthorsMichel N, Ganter K, Venzke S, Bitzegeio J, Fackler OT, Keppler OT
JournalMol Biol Cell
PubMed ID16775006
'Chemokine receptors (CKRs) are important physiological mediators of immune defense, inflammatory responses, and angiogenesis, and they have also been implicated in a number of viral disease processes. Here, we report that the Nef protein of human immunodeficiency virus (HIV) reduces cell surface levels of eight different members of the CC- ... More
A far-red fluorescent contrast agent to image epidermal growth factor receptor expression.
'Recent developments in optical technologies have the potential to improve the speed and accuracy of screening and diagnosis of curable precancerous lesions and early cancer, thereby decreasing the costs of detection and management of epithelial malignancies. The development of molecular-specific contrast agents for markers of early neoplastic transformation could improve ... More
The blood contains multiple distinct progenitor populations with clonogenic B and T lineage potential.
AuthorsUmland O, Mwangi WN, Anderson BM, Walker JC, Petrie HT,
JournalJ Immunol
PubMed ID17371970
The thymus is seeded by bone marrow-derived progenitors that circulate in the blood. Multiple cell types can be found in the thymus early after i.v. administration or in steady state, but most fail to satisfy the known characteristics of true T progenitors. Cells that do conform to classical definitions retain ... More