Protection from lethal gram-positive infection by macrophage scavenger receptor-dependent phagocytosis.
AuthorsThomas CA, Li Y, Kodama T, Suzuki H, Silverstein SC, El Khoury J
JournalJ Exp Med
PubMed ID10620613
Infections with gram-positive bacteria are a major cause of morbidity and mortality in humans. Opsonin-dependent phagocytosis plays a major role in protection against and recovery from gram-positive infections. Inborn and acquired defects in opsonin generation and/or recognition by phagocytes are associated with an increased susceptibility to bacterial infections. In contrast, ... More