Novel reprogramming of neutrophils modulates inflammation resolution during atherosclerosis.
AuthorsGeng S, Zhang Y, Lee C, Li L,
JournalSci Adv
PubMed ID30775441
Nonresolving inflammation perpetuated by innate leukocytes is involved in the pathogenesis of unstable atherosclerosis. However, the role and regulation of neutrophils related to nonresolving inflammation and atherosclerosis are poorly understood. We report herein that chronic subclinical endotoxemia, a risk factor for atherosclerosis, skewed neutrophils into a nonresolving inflammatory state with ... More