A new lock-step mechanism of matrix remodelling based on subcellular contractile events.
AuthorsCastella LF, Buscemi L, Godbout C, Meister JJ, Hinz B,
JournalJ Cell Sci
PubMed ID20427321
Myofibroblasts promote tissue contractures during fibrotic diseases. To understand how spontaneous changes in the intracellular calcium concentration, [Ca(2+)](i), contribute to myofibroblast contraction, we analysed both [Ca(2+)](i) and subcellular contractions. Contractile events were assessed by tracking stress-fibre-linked microbeads and measured by atomic force microscopy. Myofibroblasts exhibit periodic (approximately 100 seconds) [Ca(2+)](i) ... More