Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation.
AuthorsKumar JP, Tio M, Hsiung F, Akopyan S, Gabay L, Seger R, Shilo BZ, Moses K
JournalDevelopment
PubMed ID9729495
'A new conditional Egfr allele was used to dissect the roles of the receptor in eye development and to test two published models. EGFR function is necessary for morphogenetic furrow initiation, is not required for establishment of the founder R8 cell in each ommatidium, but is necessary to maintain its ... More
Effect of natural and synthetic estrogens on a549 lung cancer cells: correlation of chemical structures with cytotoxic effects.
AuthorsAndreescu S, Sadik OA, McGee DW
JournalChem Res Toxicol
PubMed ID15777086
'A series of synthetic (nonylphenol, diethylstilbestrol, and bisphenol A) and natural (quercetin, resveratrol, and genistein) phenolic estrogens were investigated for their ability to affect the viability and proliferation of A549 lung cancer cells. To assess and distinguish the cytotoxic effect of individual estrogens, we used both the MTT tetrazolium spectrophotometric ... More
DAWDLE, a forkhead-associated domain gene, regulates multiple aspects of plant development.
AuthorsMorris ER, Chevalier D, Walker JC
JournalPlant Physiol
PubMed ID16679419
Phosphoprotein-binding domains are found in many different proteins and specify protein-protein interactions critical for signal transduction pathways. Forkhead-associated (FHA) domains bind phosphothreonine and control many aspects of cell proliferation in yeast (Saccharomyces cerevisiae) and animal cells. The Arabidopsis (Arabidopsis thaliana) protein kinase-associated protein phosphatase includes a FHA domain that mediates ... More
The small ubiquitin-like modifier (SUMO) is required for gonadal and uterine-vulval morphogenesis in Caenorhabditis elegans.
AuthorsBroday L, Kolotuev I, Didier C, Bhoumik A, Gupta BP, Sternberg PW, Podbilewicz B, Ronai Z
JournalGenes Dev
PubMed ID15466489
The small ubiquitin-like modifier (SUMO) modification alters the subcellular distribution and function of its substrates. Here we show the major role of SUMO during the development of the Caenorhabditis elegans reproductive system. smo-1 deletion mutants develop into sterile adults with abnormal somatic gonad, germ line, and vulva. SMO-1::GFP reporter is ... More
Multi-photon excitation microscopy in intact animals.
AuthorsRothstein EC, Nauman M, Chesnick S, Balaban RS
JournalJ Microsc
PubMed ID16734715
Two-photon excitation fluorescence microscopy and backscattered-second harmonic generation microscopy permit the investigation of the subcellular events within living animals but numerous aspects of these experiments need to be optimized to overcome the traditional microscope geometry, motion and optical coupling to the subject. This report describes a stable system for supporting ... More
The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis.
Authors
JournalImmunity
PubMed ID27523270
Prismatic Deflection of Live Tumor Cells and Cell Clusters.
Authors
JournalACS Nano
PubMed ID30444600
New insights into organ-specific oxidative stress mechanisms using a novel biosensor zebrafish.
Authors
JournalEnviron Int
PubMed ID31645010
MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages.
Authors
JournalCell Rep
PubMed ID34133930
Identification of cell wall synthesis inhibitors active against Mycobacterium tuberculosis by competitive activity-based protein profiling.
Authors
JournalCell Chem Biol
PubMed ID34599873
Human Schwann cells exhibit long-term cell survival, are not tumorigenic and promote repair when transplanted into the contused spinal cord.
Authors
JournalGlia
PubMed ID28543541
Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis.
Authors
JournalCell Death Differ
PubMed ID26024392
Calpain drives pyroptotic vimentin cleavage, intermediate filament loss, and cell rupture that mediates immunostimulation.
Authors
JournalProc Natl Acad Sci U S A
PubMed ID30796192
Antigen-retrieval procedure for bromodeoxyuridine immunolabeling with concurrent labeling of nuclear DNA and antigens damaged by HCl pretreatment.
Authors
JournalJ Neurosci
PubMed ID17537952
Morphological profiling of tubercle bacilli identifies drug pathways of action.