Myelin basic protein gene contains separate enhancers for oligodendrocyte and Schwann cell expression.
AuthorsGow A, Friedrich VL, Lazzarini RA
JournalJ Cell Biol
PubMed ID1383235
'The DNA sequence between position +36 and -1907 of the murine myelin basic protein gene contains the enhancer and promoter elements necessary for abundant and cell specific expression in transgenic mice. Surprisingly, the pattern of expression promoted by this DNA fragment is a subset of that exhibited by the endogenous ... More
Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier.
AuthorsNeal MD, Leaphart C, Levy R, Prince J, Billiar TR, Watkins S, Li J, Cetin S, Ford H, Schreiber A, Hackam DJ,
JournalJ Immunol
PubMed ID16493066
Translocation of bacteria across the intestinal barrier is important in the pathogenesis of systemic sepsis, although the mechanisms by which bacterial translocation occurs remain largely unknown. We hypothesized that bacterial translocation across the intact barrier occurs after internalization of the bacteria by enterocytes in a process resembling phagocytosis and that ... More
Specific association of the proto-oncogene product pp60c-src with an intracellular organelle, the PC12 synaptic vesicle.
AuthorsLinstedt AD, Vetter ML, Bishop JM, Kelly RB
JournalJ Cell Biol
PubMed ID1374414
The protein product of the proto-oncogene c-src is a membrane-associated tyrosine kinase of unknown function. Identification of pp60c-src target membranes may elucidate the function of the c-src protein. The available evidence indicates that pp60c-src associates with distinct membranes within single cell types and has different distributions in different cell types. ... More
cDNAs of cell adhesion molecules of different specificity induce changes in cell shape and border formation in cultured S180 cells.
The liver cell adhesion molecule (L-CAM) and N-cadherin or adherens junction-specific CAM (A-CAM) are structurally related cell surface glycoproteins that mediate calcium-dependent adhesion in different tissues. We have isolated and characterized a full-length cDNA clone for chicken N-cadherin and used this clone to transfect S180 mouse sarcoma cells that do ... More