DLC1 interaction with a-catenin stabilizes adherens junctions and enhances DLC1 antioncogenic activity.
AuthorsTripathi V, Popescu NC, Zimonjic DB,
JournalMol Cell Biol
PubMed ID22473989
The DLC1 (for deleted in liver cancer 1) tumor suppressor gene encodes a RhoGAP protein that inactivates Rho GTPases, which are implicated in regulation of the cytoskeleton and adherens junctions (AJs), a cell-cell adhesion protein complex associated with the actin cytoskeleton. Malignant transformation and tumor progression to metastasis are often ... More
Growth arrest of epithelial cells during measles virus infection is caused by upregulation of interferon regulatory factor 1.
AuthorsYokota S, Okabayashi T, Yokosawa N, Fujii N
JournalJ Virol
PubMed ID15078941
Natural infection with measles virus (MeV) is initiated when the virus reaches epithelial cells in the respiratory tract, oropharynx, or conjunctivae. Human epithelial cells infected with MeV frequently show growth suppression. In this study, we investigated the possible mechanisms for this suppression. The bronchiolar epithelial cell A549 showed growth arrest ... More