Novel lipid-based hollow-porous microparticles as a platform for immunoglobulin delivery to the respiratory tract.
AuthorsBot AI, Tarara TE, Smith DJ, Bot SR, Woods CM, Weers JG,
JournalPharm Res
PubMed ID10801215
'Delivery of specific antibodies or immunoglobulin constructs to the respiratory tract may be useful for prophylaxis or active treatment of local or systemic disorders. Therefore, we evaluated the utility of lipid-based hollow-porous microparticles (PulmoSpheres) as a potential delivery vehicle for immunoglobulins. Lipid-based microparticles loaded with human immunoglobulin (hIgG) or control ... More
Immunostimulatory properties of a novel adjuvant administered with inactivated influenza virus vaccine.
AuthorsWellemans V, Laurent S, Hélie P, ElAzhary Y,
JournalVet Res
PubMed ID17074291
The immunopotentiating activity of a new delivery system was investigated comparatively to Alhydrogel adjuvant, as an antiviral inactivated vaccine after one injection. The efficiency of the new formulation (BioMed) was evaluated with an inactivated porcine strain of influenza (A/Sw/IN/1726/88 H1N1) in the pig model. The first assessment criteria was the ... More