CD4+ T cells mediate the protective effect of the recombinant Asp f3-based anti-aspergillosis vaccine.
AuthorsDiaz-Arevalo D, Bagramyan K, Hong TB, Ito JI, Kalkum M,
JournalInfect Immun
PubMed ID21422177
'The mortality and morbidity caused by invasive aspergillosis present a major obstacle to the successful treatment of blood cancers with hematopoietic cell transplants. Patients who receive hematopoietic cell transplants are usually immunosuppressed for extended periods, and infection with the ubiquitous mold Aspergillus fumigatus is responsible for most cases of aspergillosis. ... More
Interactions of histone H1 with phospholipids and comparison of its binding to giant liposomes and human leukemic T cells.
AuthorsZhao H, Bose S, Tuominen EK, Kinnunen PK,
JournalBiochemistry
PubMed ID15287747
Due to its net positive charge histone H1 readily associates with liposomes containing acidic phospholipids, such as phosphatidylserine (PS). Interestingly, circular dichroism reveals that while histone H1 in aqueous solutions appears as a random coil, its binding to liposomes containing PS is associated with a pronounced increase in alpha-helicity and ... More
MACROH2A2, a new member of the MARCOH2A core histone family.
AuthorsCostanzi C, Pehrson JR
JournalJ Biol Chem
PubMed ID11262398
MACROH2As are core histones that have a unique hybrid structure consisting of an amino-terminal domain that closely resembles a full-length histone H2A followed by a large nonhistone region. The human MACROH2A1 gene, on chromosome 5, encodes two MACROH2A subtypes, MACROH2A1.1 and MACROH2A1.2, produced by alternate splicing. Here we report the ... More