Methoxychlor and estradiol induce oxidative stress DNA damage in the mouse ovarian surface epithelium.
AuthorsSymonds DA, Merchenthaler I, Flaws JA,
JournalToxicol Sci
PubMed ID18502743
'Estrogenic compounds such as 17beta-estradiol (E(2)) and methoxychlor (MXC) induce oxidative stress damage in breast cells and mouse ovarian follicles, respectively. However, little is known about whether estrogenic compounds cause oxidative stress in the ovarian surface epithelium (OSE). Thus, this work tested the hypothesis that E(2) and MXC cause oxidative ... More
MiR-3120 is a mirror microRNA that targets heat shock cognate protein 70 and auxilin messenger RNAs and regulates clathrin vesicle uncoating.
AuthorsScott H, Howarth J, Lee YB, Wong LF, Bantounas I, Phylactou L, Verkade P, Uney JB,
JournalJ Biol Chem
PubMed ID22393045
'We show that a single gene locus gives rise to two fully processed and functional miRNAs, i.e. that due to imperfect base pairing, two distinct microRNAs (miRNAs) can be produced from the fully complementary DNA strands. The antisense strand encodes miR-214, which is transcribed by its own promoter, whereas a ... More
H2-K(b) and H2-D(b) regulate cerebellar long-term depression and limit motor learning.
AuthorsMcConnell MJ, Huang YH, Datwani A, Shatz CJ,
JournalProc Natl Acad Sci U S A
PubMed ID19346486
There are more than 50 class I MHC (MHCI) molecules in the mouse genome, some of which are now known to be expressed in neurons; however, the role of classical MHCI molecules in synaptic plasticity is unknown. We report that the classical MHCI molecules, H2-K(b) and H2-D(b), are co-expressed by ... More
Characterization of ß-cell plasticity mechanisms induced in mice by a transient source of exogenous insulin.
AuthorsNollevaux MC, Rahier J, Marchandise J, Thurion P, Godecharles S, Van den Steen G, Jamart J, Sempoux C, Jacquemin P, Guiot Y,
JournalAm J Physiol Endocrinol Metab
PubMed ID23403947
ß-Cell plasticity governs the adjustment of ß-cell mass and function to ensure normoglycemia. The study of how ß-cell mass is controlled and the identification of alternative sources of ß-cells are active fields of research. ß-Cell plasticity has been implicated in numerous physiological and pathological conditions. We developed a mice model ... More
NF-kappaB and Snail1a coordinate the cell cycle with gastrulation.
AuthorsLiu X, Huang S, Ma J, Li C, Zhang Y, Luo L,
JournalJ Cell Biol
PubMed ID19307597
The cell cycle needs to strictly coordinate with developmental processes to ensure correct generation of the body plan and different tissues. However, the molecular mechanism underlying the coordination remains largely unknown. In this study, we investigate how the cell cycle coordinates gastrulation cell movements in zebrafish. We present a system ... More
Aging-induced proinflammatory shift in cytokine expression profile in coronary arteries.
AuthorsCsiszar A, Ungvari Z, Koller A, Edwards JG, Kaley G,
JournalFASEB J
PubMed ID12709402
The phenotypic and functional changes of coronary arteries with aging promote ischemic heart disease. We hypothesized that these alterations reflect an aging-induced proinflammatory shift in vascular regulatory mechanisms. Thus, in isolated coronary arteries of young (3-month-old) and aged (25-month-old) male Fischer 344 rats the expression of 96 cytokines, chemokines, and ... More