Testosterone signaling through internalizable surface receptors in androgen receptor-free macrophages.
AuthorsBenten WP,Lieberherr M,Stamm O,Wrehlke C,Guo Z,Wunderlich F
JournalMolecular biology of the cell
PubMed ID10512854
Testosterone acts on cells through intracellular transcription-regulating androgen receptors (ARs). Here, we show that mouse IC-21 macrophages lack the classical AR yet exhibit specific nongenomic responses to testosterone. These manifest themselves as testosterone-induced rapid increase in intracellular free [Ca(2+)], which is due to release of Ca(2+) from intracellular Ca(2+) stores. ... More
Protein kinase C-dependent effects of 12(S)-HETE on endothelial cell vitronectin receptor and fibronectin receptor.
AuthorsTang DG,Chen YQ,Diglio CA,Honn KV
JournalThe Journal of cell biology
PubMed ID7683691
12(S)-HETE, a lipoxygenase metabolite of arachidonic acid induced a nondestructive and reversible endothelial cell (EC) retraction. 12(S)-HETE induced EC retraction was inhibited by protein kinase C inhibitors calphostin C and staurosporine but not by the protein kinase A inhibitor H8. The role of EC integrins alpha v beta 3 and ... More