Chitin is a size-dependent regulator of macrophage TNF and IL-10 production.
AuthorsDa Silva CA, Chalouni C, Williams A, Hartl D, Lee CG, Elias JA,
JournalJ Immunol
PubMed ID19265136
'Chitin is a ubiquitous polysaccharide in fungi, insects, and parasites. We hypothesized that chitin is a size-dependent regulator of innate immunity. To test this hypothesis, we characterized the effects of chitins of different sizes on murine bronchoalveolar or peritoneal macrophages. In these studies, large chitin fragments were inert, while both ... More