Head regeneration in wild-type hydra requires de novo neurogenesis.
AuthorsMiljkovic-Licina M, Chera S, Ghila L, Galliot B
JournalDevelopment
PubMed ID17301084
'Because head regeneration occurs in nerve-free hydra mutants, neurogenesis was regarded as dispensable for this process. Here, in wild-type hydra, we tested the function of the ParaHox gsx homolog gene, cnox-2, which is a specific marker for bipotent neuronal progenitors, expressed in cycling interstitial cells that give rise to apical ... More
Transgenic zebrafish reporter lines reveal conserved Toll-like receptor signaling potential in embryonic myeloid leukocytes and adult immune cell lineages.
AuthorsHall C, Flores MV, Chien A, Davidson A, Crosier K, Crosier P,
JournalJ Leukoc Biol
PubMed ID19218482
'The immune response of a host to an invading pathogen is dependent on the capacity of its immune cell compartment to recognize highly conserved pathogen components using an ancient class of pattern recognition receptors known as Toll-like receptors (TLRs). Initiation of TLR-mediated signaling results in the induction of proinflammatory cytokines ... More
Identification of antigen-presenting dendritic cells in mouse aorta and cardiac valves.
AuthorsChoi JH, Do Y, Cheong C, Koh H, Boscardin SB, Oh YS, Bozzacco L, Trumpfheller C, Park CG, Steinman RM,
JournalJ Exp Med
PubMed ID19221394
Presumptive dendritic cells (DCs) bearing the CD11c integrin and other markers have previously been identified in normal mouse and human aorta. We used CD11c promoter-enhanced yellow fluorescent protein (EYFP) transgenic mice to visualize aortic DCs and study their antigen-presenting capacity. Stellate EYFP(+) cells were readily identified in the aorta and ... More