Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemia.
AuthorsRawat VP, Cusan M, Deshpande A, Hiddemann W, Quintanilla-Martinez L, Humphries RK, Bohlander SK, Feuring-Buske M, Buske C,
JournalProc Natl Acad Sci U S A
PubMed ID14718672
Creation of fusion genes by balanced chromosomal translocations is one of the hallmarks of acute myeloid leukemia (AML) and is considered one of the key leukemogenic events in this disease. In t(12;13)(p13;q12) AML, ectopic expression of the homeobox gene CDX2 was detected in addition to expression of the ETV6-CDX2 fusion ... More
Suppression of Ras-mediated tumorigenicity and metastasis through inhibition of the Met receptor tyrosine kinase.
Authors Furge K A; Kiewlich D; Le P; Vo M N; Faure M; Howlett A R; Lipson K E; Woude G F; Webb C P;
JournalProc Natl Acad Sci U S A
PubMed ID11535809
'Mutations in the Ras family of GTP binding proteins represent one of the most frequently observed genetic alterations in human cancers. We and others have recently demonstrated that expression of Met, the tyrosine kinase receptor for hepatocyte growth factor/scatter factor (HGF/SF), is significantly up-regulated in Ras-transformed cells. Because HGF/SF-Met signaling ... More
An mRNA Splice Variant of the AFX Gene with Altered Transcriptional Activity.
Authors Yang Zhenyu; Whelan James; Babb Robert; Bowen Benjamin R;
JournalJ Biol Chem
PubMed ID11779849
Several studies indicate that FKHR and AFX, mammalian homologues of the Caenorhabditis elegans forkhead transcription factor DAF-16, function in the insulin signaling pathway. Here we describe the discovery of a novel AFX isoform, which we designated AFXzeta, in which the first 16 amino acids of the forkhead domain are not ... More
Cooperation of protein kinase A and Ras/ERK signaling pathways is required for AP-1-mediated activation of fibroblast growth factor-inducible response element (FiRE).
Authors Pursiheimo Juha-Pekka; Saari Jussi; Jalkanen Markku; Salmivirta Markku;
JournalJ Biol Chem
PubMed ID12004054
Recent studies suggest a crucial role for protein kinase A (PKA) in the regulation of growth factor signaling. However, the effect of PKA on the transcription of growth factor-responsive genes has drawn far less attention. Here we have investigated the signaling mechanisms involved in the activation of an activator protein-1 ... More