No evidence of transdifferentiation of human endothelial progenitor cells into cardiomyocytes after coculture with neonatal rat cardiomyocytes.
AuthorsGruh I, Beilner J, Blomer U, Schmiedl A, Schmidt-Richter I, Kruse ML, Haverich A, Martin U
JournalCirculation
PubMed ID16520414
'BACKGROUND: Recent studies have suggested the differentiation of human endothelial progenitor cells (huEPCs) isolated from peripheral blood into cardiomyocytes. This study investigates whether, when cocultured, neonatal rat cardiomyocytes (NRCMs) can induce transdifferentiation of huEPCs into cardiomyocytes. METHODS AND RESULTS: Coculture experiments with 1,1''-dioctadecyl-3,3,3'',3''-tetramethylindocarbocyanine (DiI)-labeled huEPCs and NRCMs have been performed. ... More
Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma.
AuthorsKhakoo AY, Pati S, Anderson SA, Reid W, Elshal MF, Rovira II, Nguyen AT, Malide D, Combs CA, Hall G, Zhang J, Raffeld M, Rogers TB, Stetler-Stevenson W, Frank JA, Reitz M, Finkel T,
JournalJ Exp Med
PubMed ID16636132
'Emerging evidence suggests that both human stem cells and mature stromal cells can play an important role in the development and growth of human malignancies. In contrast to these tumor-promoting properties, we observed that in an in vivo model of Kaposi''s sarcoma (KS), intravenously (i.v.) injected human mesenchymal stem cells ... More
Intra-vital fluorescence microscopy for intra-myocardial graft detection following cell transplantation.
AuthorsRuhparwar A, Kofidis T, Ruebesamen N, Karck M, Haverich A, Martin U
JournalInt J Cardiovasc Imaging
PubMed ID16175449
'INTRODUCTION: The aim of our study was the development of a potentially clinically applicable approach, which allows for intra-myocardial detection of the transplanted cells without the need for collection of tissue samples. Intra-myocardial transplantation of myocytes and bone marrow derived cells is currently under clinical evaluation as a therapy of ... More
Application and limitations of chloromethyl-benzamidodialkylcarbocyanine for tracing cells used in bone Tissue engineering.
AuthorsKruyt MC, De Bruijn J, Veenhof M, Oner FC, Van Blitterswijk CA, Verbout AJ, Dhert WJ,
JournalTissue Eng
PubMed ID12625959
Bone tissue engineering has the potential to provide us with an autologous bone substitute. Despite extensive research to optimize the technique, little is known about the survival and function of the cells after implantation. To monitor the cells, in vivo labeling is the method of choice. In this study we ... More
Mesenchymal stem cells: isolation, characterisation and in vivo fluorescent dye tracking.
Cell therapies have been used to regenerate the heart by direct myocardial delivery, by coronary infusion and by surface attached scaffolds. Multipotent mesenchymal stem cells (MSC) with capacity to differentiate into cardiomyocytes and other cell lines have been predominantly trialled in rodents. However, large animal models are increasingly needed to ... More
Deoxycholate promotes survival of breast cancer cells by reducing the level of pro-apoptotic ceramide.
AuthorsKrishnamurthy K, Wang G, Rokhfeld D, Bieberich E,
JournalBreast Cancer Res
PubMed ID19087284
INTRODUCTION: At physiologic concentration in serum, the bile acid sodium deoxycholate (DC) induces survival and migration of breast cancer cells. Here we provide evidence of a novel mechanism by which DC reduces apoptosis that is induced by the sphingolipid ceramide in breast cancer cells. METHODS: Murine mammacarcinoma 4T1 cells were ... More
Lipids isolated from bone induce the migration of human breast cancer cells.
AuthorsSilva J, Dasgupta S, Wang G, Krishnamurthy K, Ritter E, Bieberich E
JournalJ Lipid Res
PubMed ID16439808
Bone is the most common site to which breast cancer cells metastasize. We found that osteoblast-like MG63 cells and human bone tissue contain the bile acid salt sodium deoxycholate (DC). MG63 cells take up and accumulate DC from the medium, suggesting that the bone-derived DC originates from serum. DC released ... More
Co-delivery of miR-181a and melphalan by lipid nanoparticles for treatment of seeded retinoblastoma.
Authors
JournalJ Control Release
PubMed ID30776396
Transplantation of human induced pluripotent stem cell-derived cardiomyocytes improves myocardial function and reverses ventricular remodeling in infarcted rat hearts.
Authors
JournalStem Cell Res Ther
PubMed ID32085809
Thermal constraints on in vivo optogenetic manipulations.
Authors
JournalNat Neurosci
PubMed ID31209378
TAG-1 Multifunctionality Coordinates Neuronal Migration, Axon Guidance, and Fasciculation.
Authors
JournalCell Rep
PubMed ID31995756
Sensory coding and the causal impact of mouse cortex in a visual decision.
Authors
JournalElife
PubMed ID34328419
Modulating Bone Marrow Hematopoietic Lineage Potential to Prevent Bone Metastasis in Breast Cancer.
Authors
JournalCancer Res
PubMed ID30065048
Extensive cone-dependent spectral opponency within a discrete zone of the lateral geniculate nucleus supporting mouse color vision.
Authors
JournalCurr Biol
PubMed ID34111401
Distributed coding of choice, action and engagement across the mouse brain.
Authors
JournalNature
PubMed ID31776518
Effectiveness of porous silicon nanoparticle treatment at inhibiting the migration of a heterogeneous glioma cell population.