Caudalization of neural fate by tissue recombination and bFGF.
AuthorsCox WG, Hemmati-Brivanlou A
JournalDevelopment
PubMed ID8575335
'In order to study anteroposterior neural patterning in Xenopus embryos, we have developed a novel assay using explants and tissue recombinants of early neural plate. We show, by using region-specific neural markers and lineage tracing, that posterior axial tissue induces midbrain and hindbrain fates from prospective forebrain. The growth factor ... More
Induction of anteroposterior neural pattern in Xenopus: evidence for a quantitative mechanism.
AuthorsDoniach T, Musci TJ
JournalMech Dev
PubMed ID8645606
'The developing vertebrate nervous system arises from ectoderm in response to inductive signals from the dorsal mesoderm, or Spemann organizer. It displays pronounced anteroposterior (AP) pattern, but the mechanism that generates this pattern is poorly understood. We demonstrate that the inducing ability of dorsal mesoderm is regionalized along the AP ... More