Extracellular vesicle-mediated transfer of processed and functional RNY5 RNA.
AuthorsChakrabortty SK, Prakash A, Nechooshtan G, Hearn S, Gingeras TR,
Journal
PubMed ID26392588
Extracellular vesicles (EVs) have been proposed as a means to promote intercellular communication. We show that when human primary cells are exposed to cancer cell EVs, rapid cell death of the primary cells is observed, while cancer cells treated with primary or cancer cell EVs do not display this response. ... More
Vascular endothelial growth factor-C protects prostate cancer cells from oxidative stress by the activation of mammalian target of rapamycin complex-2 and AKT-1.
AuthorsMuders MH, Zhang H, Wang E, Tindall DJ, Datta K,
JournalCancer Res
PubMed ID19638584
Recurrence and subsequent metastatic transformation of cancer develops from a subset of malignant cells, which show the ability to resist stress and to adopt to a changing microenvironment. These tumor cells have distinctly different growth factor pathways and antiapoptotic responses compared with the vast majority of cancer cells. Long-term therapeutic ... More
Secretion of the human T cell leukemia virus type I transactivator protein tax.
AuthorsAlefantis T, Mostoller K, Jain P, Harhaj E, Grant C, Wigdahl B
JournalJ Biol Chem
PubMed ID15659397
Human T cell leukemia virus type I (HTLV-I) is the etiologic agent of adult T cell leukemia and HTLV-I-associated myelopathy/tropical spastic paraparesis. The HTLV-I protein Tax is well known as a transcriptional transactivator and inducer of cellular transformation. However, it is also known that extracellular Tax induces the production and ... More
PKCd regulates integrin aVß3 expression and transformed growth of K-ras dependent lung cancer cells.
AuthorsSymonds JM, Ohm AM, Tan AC, Reyland ME,
JournalOncotarget
PubMed ID26918447
We have previously shown that Protein Kinase C delta (PKCd) functions as a tumor promoter in non-small cell lung cancer (NSCLC), specifically in the context of K-ras addiction. Here we define a novel PKCd -> integrin aVß3 ->Extracellular signal-Regulated Kinase (ERK) pathway that regulates the transformed growth of K-ras dependent ... More
Liposomal Delivery of miR-34b-5p Induced Cancer Cell Death in Thyroid Carcinoma.
AuthorsMaroof H, Islam F, Dong L, Ajjikuttira P, Gopalan V, McMillan NAJ, Lam AK
JournalCells
PubMed ID30544959
This study aims to determine the functional roles of microRNA-34b-5p (miR-34b) in the suppression of anaplastic thyroid carcinoma. We used hydration-of-freeze-dried-matrix (HFDM) formulated liposomes (liposome-loaded miR-34b) for effective delivery of miR-34b to anaplastic thyroid carcinoma in vitro and in vivo. Real time polymerase chain was used to determine the level ... More
Novel Targeting of Transcription and Metabolism in Glioblastoma.
AuthorsSu YT, Chen R, Wang H, Song H, Zhang Q, Chen LY, Lappin H, Vasconcelos G, Lita A, Maric D, Li A, Celiku O, Zhang W, Meetze K, Estok T, Larion M, Abu-Asab M, Zhuang Z, Yang C, Gilbert MR, Wu J,
JournalClin Cancer Res
PubMed ID29254993
Purpose: Glioblastoma (GBM) is highly resistant to treatment, largely due to disease heterogeneity and resistance mechanisms. We sought to investigate a promising drug that can inhibit multiple aspects of cancer cell survival mechanisms and become an effective therapeutic for GBM patients.Experimental Design: To investigate TG02, an agent with known penetration ... More
Protective Effects of CISD2 and Influence of Curcumin on CISD2 Expression in Aged Animals and Inflammatory Cell Model.
AuthorsLin CC, Chiang TH, Sun YY, Lin MS,
JournalNutrients
PubMed ID30934593
Inflammation and mitochondrial dysfunction have been linked to trauma, neurodegeneration, and aging. Impairment of CISD2 expression may trigger the aforementioned pathological conditions in neural cells. We previously reported that curcumin attenuates the downregulation of CISD2 in animal models of spinal cord injury and lipopolysaccharide (LPS)-treated neuronal cells. In this study, ... More