'Modulation of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13- acetate (TPA) disrupts the cell-cell junctions of the epithelial cell line LLC-PK1. To examine the role of specific PKC isoforms in this process we have created modified LLC-PK1 subclones that express wild- type and dominant negative versions of PKC-alpha under control of ... More