Proteolysis of CCN1 by plasmin: functional implications.
AuthorsPendurthi UR,Tran TT,Post M,Rao LV
JournalCancer research
PubMed ID16266990
Plasmin is shown to play a crucial role in many pathophysiological processes, primarily through its ability to degrade extracellular matrix and/or mobilizing growth factors that are sequestered in the extracellular matrix. CCN1 is a matricellular protein whose expression is upregulated in cancer and various vascular diseases. The present study was ... More
A serine/threonine-rich motif is one of three nuclear localization signals that determine unidirectional transport of the mineralocorticoid receptor to the nucleus.
AuthorsWalther RF, Atlas E, Carrigan A, Rouleau Y, Edgecombe A, Visentin L, Lamprecht C, Addicks GC, Haché RJ, Lefebvre YA,
JournalJ Biol Chem
PubMed ID15737989
The mineralocorticoid receptor (MR) is a tightly regulated nuclear hormone receptor that selectively transmits corticosteroid signals. Steroid treatment transforms MR from a transcriptionally inert state, in which it is distributed equally between the nucleus and cytoplasm, to an active completely nuclear transcription factor. We report here that MR is an ... More