Proteolysis of CCN1 by plasmin: functional implications.
AuthorsPendurthi UR,Tran TT,Post M,Rao LV
JournalCancer research
PubMed ID16266990
Plasmin is shown to play a crucial role in many pathophysiological processes, primarily through its ability to degrade extracellular matrix and/or mobilizing growth factors that are sequestered in the extracellular matrix. CCN1 is a matricellular protein whose expression is upregulated in cancer and various vascular diseases. The present study was ... More