The large conductance potassium channel beta-subunit can interact with and modulate the functional properties of a calcium-activated chloride channel, CLCA1.
Authors Greenwood Iain A; Miller Lisa J; Ohya Susumu; Horowitz Burton;
JournalJ Biol Chem
PubMed ID11994272
'We have recently compared the biophysical and pharmacological properties of native Ca(2+)-activated Cl(-) currents in murine portal vein with mCLCA1 channels cloned from murine portal vein myocytes (Britton, F. C., Ohya, S., Horowitz, B., and Greenwood, I. A. (2002) J. Physiol. (Lond.) 539, 107-117). These channels shared a similar relative ... More
Extension of life-span by introduction of telomerase into normal human cells [see comments]
AuthorsBodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, Harley CB, Shay JW, Lichtsteiner S, Wright WE
JournalScience
PubMed ID9454332
Normal human cells undergo a finite number of cell divisions and ultimately enter a nondividing state called replicative senescence. It has been proposed that telomere shortening is the molecular clock that triggers senescence. To test this hypothesis, two telomerase-negative normal human cell types, retinal pigment epithelial cells and foreskin fibroblasts, ... More
Subtraction hybridization identifies a transformation progression- associated gene PEG-3 with sequence homology to a growth arrest and DNA damage-inducible gene [published erratum appears in Proc Natl Acad Sci U S A 1997 Oct 28;94(22):12241]
AuthorsSu ZZ, Shi Y, Fisher PB
JournalProc Natl Acad Sci U S A
PubMed ID9256446
Cancer is a progressive multigenic disorder characterized by defined changes in the transformed phenotype that culminates in metastatic disease. Determining the molecular basis of progression should lead to new opportunities for improved diagnostic and therapeutic modalities. Through the use of subtraction hybridization, a gene associated with transformation progression in virus- ... More
Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury.
AuthorsDore S, Takahashi M, Ferris CD, Hester LD, Guastella D, Snyder SH
JournalProc Natl Acad Sci U S A
PubMed ID10051662
Heme oxygenase (HO) catalyzes the conversion of heme to carbon monoxide, iron, and biliverdin, which is immediately reduced to bilirubin (BR). Two HO active isozymes exist: HO1, an inducible heat shock protein, and HO2, which is constitutive and highly concentrated in neurons. We demonstrate a neuroprotective role for BR formed ... More
A 40-bp RNA element that mediates stabilization of vascular endothelial growth factor mRNA by HuR.
Authors Goldberg-Cohen Ilana; Furneauxb Henry; Levy Andrew P;
JournalJ Biol Chem
PubMed ID11834731
VEGF is a critical mediator of hypoxia-induced angiogenesis in numerous physiological and pathophysiological conditions. The hypoxic induction of VEGF is due in large part to an increase in the stability of its mRNA. We recently demonstrated that the stabilization of VEGF mRNA by hypoxia is dependent upon the RNA-binding protein ... More