Phosphatidylinositide 3-kinase priming couples c-FLIP to T cell activation.
AuthorsFang LW, Tai TS, Yu WN, Liao F, Lai MZ,
JournalJ Biol Chem
PubMed ID14578361
Cellular FLICE (FADD-like interleukin-1-beta-converting enzyme)-inhibitory protein (c-FLIP) inhibits death receptor-induced apoptosis by binding to FADD (Fas-associated death domain protein) and pro-caspase-8. c-FLIP has also been shown to transmit activation signals and to enhance interleukin (IL)-2 production. However, c-FLIP-mediated T cell activation is difficult to detect in most cells. We found ... More
PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin.
AuthorsSteiner H, Winkler E, Edbauer D, Prokop S, Basset G, Yamasaki A, Kostka M, Haass C.
JournalJ Biol Chem
PubMed ID12198112
The Alzheimer disease-associated presenilin (PS) proteins apparently provide the active site of gamma-secretase, an unusual intramembrane-cleaving aspartyl protease. PSs principally occur as high molecular weight protein complexes that contain nicastrin (Nct) and additional so far unidentified components. Recently, PEN-2 has been implicated in gamma-secretase function. Here we identify PEN-2 as ... More