Intracellular antibody-caspase-mediated cell killing: An approach for application in cancer therapy.
AuthorsTse E, Rabbitts TH
JournalProc Natl Acad Sci
PubMed ID11050246
Antibodies have been expressed inside cells in an attempt to ablate the function of oncogene products. To make intracellular antibodies more generally applicable and effective in cancer therapy, we have devised a method in which programmed cell death or apoptosis can be triggered by specific antibody-antigen interaction. When intracellular antibodies ... More