A Trim5-cyclophilin A fusion protein found in owl monkey kidney cells can restrict HIV-1.
AuthorsNisole S, Lynch C, Stoye JP, Yap MW,
JournalProc Natl Acad Sci U S A
PubMed ID15326303
'Lv1 restriction of HIV-1 in the cells of Old World monkeys is associated with the expression of the Trim5 gene. Uniquely, in owl monkey kidney cells, HIV-1 restriction is dependent on the ability of incoming viral capsid protein to bind cyclophilin A (CypA). Cloning of the owl monkey Trim5 gene ... More