Sortase A localizes to distinct foci on the Streptococcus pyogenes membrane.
AuthorsRaz A, Fischetti VA,
JournalProc Natl Acad Sci U S A
PubMed ID19017791
'Cell wall peptidoglycan-anchored surface proteins are essential virulence factors in many gram-positive bacteria. The attachment of these proteins to the peptidoglycan is achieved through a transpeptidation reaction, whereby sortase cleaves a conserved C-terminal LPXTG motif and covalently attaches the protein to the peptidoglycan precursor lipid II. It is unclear how ... More