Dexras1/AGS-1 inhibits signal transduction from the Gi-coupled formyl peptide receptor to Erk-1/2 MAP kinases.
Authors Graham Timothy E; Prossnitz Eric R; Dorin Richard I;
JournalJ Biol Chem
PubMed ID11751935
'Dexras1 is a novel GTP-binding protein (G protein) that was recently discovered on the basis of rapid mRNA up-regulation by glucocorticoids in murine AtT-20 corticotroph cells and in several primary tissues. The human homologue of Dexras1, termed activator of G protein signaling-1 (AGS-1), has been reported to stimulate signaling by ... More
In Saccharomyces cerevisiae, the inositol polyphosphate kinase activity of Kcs1p is required for resistance to salt stress, cell wall integrity, and vacuolar morphogenesis.
Authors Dubois Evelyne; Scherens Bart; Vierendeels Fabienne; Ho Melisa M W; Messenguy Francine; Shears Stephen B;
JournalJ Biol Chem
PubMed ID11956213
A problem for inositol signaling is to understand the significance of the kinases that convert inositol hexakisphosphate to diphosphoinositol polyphosphates. This kinase activity is catalyzed by Kcs1p in the yeast Saccharomyces cerevisiae. A kcs1Delta yeast strain that was transformed with a specifically ... More
Angiogenic bFGF expression from gas-plasma treated scaffolds.
AuthorsBailey SR, Polan JL, Morse B, Wetherold S, Villanueva-Vedia RE, Waggoner D, Phelix C, Barera-Roderiquiz E, Goswami N, Munoz O, Agrawal CM,
JournalCardiovasc Radiat Med
PubMed ID12974371
PURPOSE: In vivo experiments indicate that gas-plasma-treated D,L-polylactide polymers expressing basic fibroblast growth factor (bFGF) exhibit enhanced angiogenesis. bFGF is not a single entity, but it is instead a family of isoforms. Consequently, we sought to determine which bFGF isoforms and levels initiate angiogenesis in nude mice peritoneums. METHODS: Cytoplasmic ... More
Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex.
Authors Kirschner L S; Carney J A; Pack S D; Taymans S E; Giatzakis C; Cho Y S; Cho-Chung Y S; Stratakis C A;
JournalNat Genet
PubMed ID10973256
Carney complex (CNC) is a multiple neoplasia syndrome characterized by spotty skin pigmentation, cardiac and other myxomas, endocrine tumours and psammomatous melanotic schwannomas. CNC is inherited as an autosomal dominant trait and the genes responsible have been mapped to 2p16 and 17q22-24 (refs 6, 7). Because of its similarities to ... More
Opposing action of estrogen receptors alpha and beta on cyclin D1 gene expression.
Authors Liu Meng-Min; Albanese Chris; Anderson Carol M; Hilty Kristin; Webb Paul; Uht Rosalie M; Price Richard H Jr; Pestell Richard G; Kushner Peter J;
JournalJ Biol Chem
PubMed ID11986316
Induction of cyclin D1 gene transcription by estrogen receptor alpha (ERalpha) plays an important role in estrogen-mediated proliferation. There is no classical estrogen response element in the cyclin D1 promoter, and induction by ERalpha has been mapped to an alternative response element, a cyclic AMP-response element at -57, with possible ... More