'Besnoitia besnoiti, an apicomplexan parasite of cattle being considered as emergent in Europe, replicates fast in host endothelial cells during acute infection and is in considerable need for energy, lipids and other building blocks for offspring formation. Apicomplexa are generally considered as defective in cholesterol synthesis and have to scavenge ... More
Mitochondrial Dysfunction in Huntington's Disease; Interplay Between HSF1, p53 and PGC-1a Transcription Factors.
AuthorsIntihar TA, Martinez EA, Gomez-Pastor R,
JournalFront Cell Neurosci
PubMed ID30941017
Huntington's disease (HD) is a neurodegenerative disease caused by an expanded CAG repeat in the huntingtin (HTT) gene, causing the protein to misfold and aggregate. HD progression is characterized by motor impairment and cognitive decline associated with the preferential loss of striatal medium spiny neurons (MSNs). The mechanisms that determine ... More
Silver/silver chloride (Ag/AgCl) nanoparticles synthesized from Azadirachta indica lalex and its antibiofilm activity against fluconazole resistant Candida tropicalis.
AuthorsAl Aboody MS,
JournalArtif Cells Nanomed Biotechnol
PubMed ID31137983
In this study, latex of Azadirachta indica was used for the synthesis of silver nanoparticles (AgNP). UV-visible spectroscopy revealed the formation of AgNPs and the absorption band optimized at 442?nm. Fourier transform infrared (FTIR) spectroscopy shows different functional groups (carboxyl, amine and hydroxyl) of biomolecule which are responsible for reduction ... More