DNAM-1 and PVR regulate monocyte migration through endothelial junctions.
AuthorsReymond N, Imbert AM, Devilard E, Fabre S, Chabannon C, Xerri L, Farnarier C, Cantoni C, Bottino C, Moretta A, Dubreuil P, Lopez M
JournalJ Exp Med
PubMed ID15136589
'DNAX accessory molecule 1 (DNAM-1; CD226) is a transmembrane glycoprotein involved in T cell and natural killer (NK) cell cytotoxicity. We demonstrated recently that DNAM-1 triggers NK cell-mediated killing of tumor cells upon engagement by its two ligands, poliovirus receptor (PVR; CD155) and Nectin-2 (CD112). In the present paper, we ... More
Efficient polyethylenimine-mediated gene delivery proceeds via a caveolar pathway in HeLa cells.
AuthorsGabrielson NP, Pack DW,
JournalJ Control Release
PubMed ID19217921
Most in vivo gene therapies will require cell-specific targeting. Although vector targeting through ligand attachment has met with success in generating gene delivery particles that are capable of specific cellular interactions, little attention has been given to the possible effects of such ligands on subsequent intracellular processing. In this study, ... More