Chromatin of the Barr body: histone and non-histone proteins associated with or excluded from the inactive X chromosome.
AuthorsChadwick BP, Willard HF
JournalHum Mol Genet
PubMed ID12915472
'The Barr body has long been recognized as the cytological manifestation of the inactive X chromosome (Xi) in interphase nuclei. Despite being known for over 50 years, relatively few components of the Barr body have been identified. In this study, we have screened over 30 histone variants, modified histones and ... More
Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi-like organelle to peripheral vacuoles in the primitive eukaryote Giardia lamblia.
AuthorsTouz MC, Kulakova L, Nash TE
JournalMol Biol Cell
PubMed ID15107467
Giardia lamblia is an early branching protist that possesses peripheral vacuoles (PVs) with characteristics of lysosome-like organelles, located underneath the plasma membrane. In more evolved cells, lysosomal protein trafficking is achieved by cargo recognition involving adaptor protein (AP) complexes that recognize specific amino acid sequences (tyrosine and/or dileucine motifs) within ... More
Active and passive mechanisms drive secretory granule biogenesis during differentiation of the intestinal parasite Giardia lamblia.
AuthorsGottig N, Elías EV, Quiroga R, Nores MJ, Solari AJ, Touz MC, Luján HD
JournalJ Biol Chem
PubMed ID16611634
The parasitic protozoan Giardia lamblia undergoes important changes to survive outside the intestine of its host by differentiating into infective cysts. During encystation, three cyst wall proteins (CWPs) are specifically expressed and concentrated within encystation-specific secretory vesicles (ESVs). ESVs are electron-dense secretory granules that transport CWPs before exocytosis and extracellular ... More