JNK phosphorylates synaptotagmin-4 and enhances Ca2+-evoked release.
AuthorsMori Y, Higuchi M, Hirabayashi Y, Fukuda M, Gotoh Y,
JournalEMBO J
PubMed ID18046461
'Ca2+ influx induced by membrane depolarization triggers the exocytosis of secretory vesicles in various cell types such as endocrine cells and neurons. Peptidyl growth factors enhance Ca2+-evoked release, an effect that may underlie important adaptive responses such as the long-term potentiation of synaptic transmission induced by growth factors. Here, we ... More