Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes.
AuthorsFein JA, Sokolow S, Miller CA, Vinters HV, Yang F, Cole GM, Gylys KH,
JournalAm J Pathol
PubMed ID18467692
The amyloid cascade hypothesis proposes that amyloid beta (Abeta) pathology precedes and induces tau pathology, but the neuropathological connection between these two lesions has not been demonstrated. We examined the regional distribution and co-localization of Abeta and phosphorylated tau (p-tau) in synaptic terminals of Alzheimer's disease brains. To quantitatively examine ... More