Asymmetrical beta-actin mRNA translation in growth cones mediates attractive turning to netrin-1.
AuthorsLeung KM, van Horck FP, Lin AC, Allison R, Standart N, Holt CE
JournalNat Neurosci
PubMed ID16980963
Local protein synthesis regulates the turning of growth cones to guidance cues, yet little is known about which proteins are synthesized or how they contribute to directional steering. Here we show that beta-actin mRNA resides in Xenopus laevis retinal growth cones where it binds to the RNA-binding protein Vg1RBP. Netrin-1 ... More
SLC26A7: a basolateral Cl-/HCO3- exchanger specific to intercalated cells of the outer medullary collecting duct.
AuthorsPetrovic S, Barone S, Xu J, Conforti L, Ma L, Kujala M, Kere J, Soleimani M
JournalAm J Physiol Renal Physiol
PubMed ID12965893
The outer medullary collecting duct (OMCD) plays an important role in bicarbonate reabsorption and acid-base regulation. An apical V-type H+-ATPase and a basolateral Cl-/HCO3- exchanger, located in intercalated cells of OMCD, mediate the bicarbonate reabsorption. Here we report the identification of a new basolateral Cl-/HCO3- exchanger in OMCD intercalated cells ... More
Distinct endosomal compartments in early trafficking of low density lipoprotein-derived cholesterol.
AuthorsSugii S, Reid PC, Ohgami N, Du H, Chang TY
JournalJ Biol Chem
PubMed ID12721287
We previously studied the early trafficking of low density lipoprotein (LDL)-derived cholesterol in mutant Chinese hamster ovary cells defective in Niemann-Pick type C1 (NPC1) using cyclodextrin (CD) to monitor the arrival of cholesterol from the cell interior to the plasma membrane (PM) (Cruz, J. C., Sugii, S., Yu, C., and ... More