New Zenon Alexa Fluor Plus Labeling Reagents are superior in three ways: improved bioconjugation for brighter signal, redesigned protein for robust screening regardless of IgG isotype, and new, more sensitive fluorophores.
Novel designs of multivalent anti-CD20 humanized antibodies as improved lymphoma therapeutics.
Authors:Rossi EA, Goldenberg DM, Cardillo TM, Stein R, Wang Y, Chang CH,
Journal:Cancer Res
PubMed ID:18922911
'Multivalent antibodies, either monospecific or bispecific, may improve the efficacy of current therapeutic interventions involving a single monoclonal antibody (mAb). We have applied the Dock-and-Lock (DNL) method, a new platform technology for the site-specific and covalent assembly of modular components into stably tethered complexes of defined composition, to prepare a ... More
A general process for the development of peptide-based immunoassays for monoclonal antibodies.
'PURPOSE: Monoclonal antibodies (mAb) are an important and growing class of cancer therapeutics, but pharmacokinetic analyses have in many cases been constrained by the lack of standard and robust pharmacologic assays. The goal of this project was to develop a general method for the production of immunoassays that can measure ... More