An isoform of ZBP-89 predisposes the colon to colitis.
AuthorsLaw DJ, Labut EM, Adams RD, Merchant JL,
JournalNucleic Acids Res
PubMed ID16517939
Alternative splicing enables expression of functionally diverse protein isoforms. The structural and functional complexity of zinc-finger transcription factor ZBP-89 suggests that it may be among the class of alternatively spliced genes. We identified a human ZBP-89 splice isoform (ZBP-89(DeltaN)), which lacks amino terminal residues 1-127 of the full-length protein (ZBP-89(FL)). ... More