PCDNA6⁄TR, 20UG VIAL

Name: PCDNA6&frasl;TR, 20UG VIAL
SKU: 351592

货号 351592

价格（CNY)

规格

Unit Size1 each

引用和文献 (1)

引用和文献

Abstract

Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector.

Authors:van de Wetering M, Oving I, Muncan V, Pon Fong MT, Brantjes H, van Leenen D, Holstege FC, Brummelkamp TR, Agami R, Clevers H,

Journal:EMBO Rep

PubMed ID:12776180

'We have designed a doxycycline-regulated form of the H1 promoter of RNA polymerase III that allows the inducible knockdown of gene expression by small interfering RNAs (siRNAs). As a proof-of-principle, we have targeted beta-catenin in colorectal cancer (CRC) cells. T-cell factor (TCF) target-gene expression is induced by accumulated beta-catenin, and ... More