Yes. RNA extraction can be performed after using Syn-PER Synaptic Protein Extraction Reagent (Cat. No. 87793).
After the lysis step, you will need to perform two centrifugations (step 4 and 5 in the manual, the first at low speed to discard the tissue or cell debris. The second one, at higher speed, will pellet synaptosomes. The supernatant arising from this step will include the cytosolic fraction (step 6).
If the synaptosomes are intact and have RNA inside, the RNA should be extractable by the kit or method of your choice.
Please note: This extraction procedure should be experimentally tested.
Find additional tips, troubleshooting help, and resources within our RNA Sample Collection, Protection, and Isolation Support Center.