Innate immune recognition triggers secretion of lysosomal enzymes by macrophages.
Authors:Lackman RL, Jamieson AM, Griffith JM, Geuze H, Cresswell P
Journal:Traffic
PubMed ID:17555533
'Gamma interferon-induced lysosomal thiolreductase (GILT) is expressed constitutively in antigen-presenting cells, where it reduces disulfide bonds to facilitate antigen presentation. GILT is synthesized as an enzymatically active precursor protein and is processed in early endosomes to yield the mature enzyme. The exposure of the promonocytic cell line THP-1 to Escherichia ... More