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Nitro Blue Tetrazolium chloride, 98+%
Intense blue dye used in histochemistry determinations | CAS: 298-83-9 | C40H30Cl2N10O6 | 817.644 g/mol
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化学标识符
CAS298-83-9
IUPAC Name2-{3,3'-dimethoxy-4'-[3-(4-nitrophenyl)-5-phenyl-3H-1,2λ⁵,3,4-tetrazol-2-ylium-2-yl]-[1,1'-biphenyl]-4-yl}-3-(4-nitrophenyl)-5-phenyl-3H-1,2λ⁵,3,4-tetrazol-2-ylium dichloride
Molecular FormulaC40H30Cl2N10O6
InChI KeyFSVCQIDHPKZJSO-UHFFFAOYSA-L
SMILES[Cl-].[Cl-].COC1=CC(=CC=C1[N+]1=NC(=NN1C1=CC=C(C=C1)[N+]([O-])=O)C1=CC=CC=C1)C1=CC=C(C(OC)=C1)[N+]1=NC(=NN1C1=CC=C(C=C1)[N+]([O-])=O)C1=CC=CC=C1
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规格
规格表
规格表Assay (HPLC)≥98.0%
Solution TestYellow transparent solution (5% in methanol)
FormPowder
Water Content (Karl Fischer Titration)≤4.5%
Thin Layer ChromatographySingle spot
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Intense blue dye used in histochemistry determinations.Nitro Blue Tetrazolium chloride is used to confirm diagnosis of chronic granulomatous disease. It is a microscopic stain, which is used to detect dehydrogenases and alkaline phosphatase. It acts as an NADPH-diaphorase substrate that competitively inhibits nitric oxide synthase. Further, it is used in immunology for detection of alkaline phosphatase. In addition to this, it acts as an oxidant.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Intense blue dye used in histochemistry determinations.Nitro Blue Tetrazolium chloride is used to confirm diagnosis of chronic granulomatous disease. It is a microscopic stain, which is used to detect dehydrogenases and alkaline phosphatase. It acts as an NADPH-diaphorase substrate that competitively inhibits nitric oxide synthase. Further, it is used in immunology for detection of alkaline phosphatase. In addition to this, it acts as an oxidant.
Solubility
Soluble in water, ethanol and methanol.
Notes
Light sensitive. Store in a cool place. Incompatible with strong oxidizing agents.
Intense blue dye used in histochemistry determinations.Nitro Blue Tetrazolium chloride is used to confirm diagnosis of chronic granulomatous disease. It is a microscopic stain, which is used to detect dehydrogenases and alkaline phosphatase. It acts as an NADPH-diaphorase substrate that competitively inhibits nitric oxide synthase. Further, it is used in immunology for detection of alkaline phosphatase. In addition to this, it acts as an oxidant.
Solubility
Soluble in water, ethanol and methanol.
Notes
Light sensitive. Store in a cool place. Incompatible with strong oxidizing agents.
RUO – Research Use Only
General References:
- Materska, M.; Konopacka, M.; Rogoliński, J.; Ślosarek, K. Antioxidant activity and protective effects against oxidative damage of human cells induced by X-radiation of phenolic glycosides isolated from pepper fruits Capsicum annuum L. Food Chem. 2015, 168, 546-553.
- Xiong, B.; Xu, R.; Zhou, R.; He, Y.; Yeung, E. S. Preventing UV induced cell damage by scavenging reactive oxygen species with enzyme-mimic Au-Pt nanocomposites. Talanta 2014, 120, 262-267.