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Thermo Scientific Chemicals
Clofibrate, 95+%
CAS: 637-07-0 | C12H15ClO3 | 242.70 g/mol
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Beilstein1913459
CAS637-07-0
ChEBICHEBI:3750
化å¦å称或ææ–™Clofibrate
DOT ä¿¡æ¯Transport Hazard Class: 9; Packing Group: III; Proper Shipping Name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S.
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It is a lipid-lowering agent used for controlling the high cholesterol and triacylglyceride level in the blood. It increases lipoprotein lipase activity to promote the conversion of VLDL to LDL, and hence reduce the level of VLDL. It can increase the level of HDL as well. Clofibrate is a ligand agonist for PPARα (peroxisome proliferator-activated receptor α), or an inducer of cytochromes P450’s CYP4A1 and CYP4A3.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Solubility
Soluble to 100 mM in DMSO.
Notes
Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents, heat, bases. Store in refrigerator.
Soluble to 100 mM in DMSO.
Notes
Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents, heat, bases. Store in refrigerator.
RUO – Research Use Only
General References:
- S Oikawa; H Midorikawa.[Clofibrate treatment of hyperlipoproteinemia]. Nippon rinsho. Japanese journal of clinical medicine.1994, 52 (12), 3285-3291.
- W Reuter; A Seifert. [The treatment of essential hyperlipidemia with clofibrate]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete. 1969, 24 (1), Suppl-Supp7.